"It's a simple fact that fructose is metoblized in to fat at a much faster rate that sucrose and other sugars."
Sucrose is fructose. Sucrose is a fructose bound to a glucose or a 50% fructose and 50% glucose. HFCS is 55% fructose and 42% glucose. I'm sure that extra 5% is totally what tipped Johnny into obesity. True, fructose bypasses a key regulatory step in the metabolic pathway but that argument ignores every other regulatory process in the human body and forgets that HFCS is being compared to sucrose and not pure glucose or complex carbohydrates.
http://www.ajcn.org/content/88/6/1738S.short
"Compared with pure glucose, fructose is thought to be associated with insufficient secretion of insulin and leptin and suppression of ghrelin. However, when HFCS is compared with sucrose, the more commonly consumed sweetener, such differences are not apparent, and appetite and energy intake do not differ in the short-term."
http://jn.nutrition.org/content/139/6/1253S.short
"On balance, the case for fructose being less satiating than glucose or HFCS being less satiating than sucrose is not compelling."
http://www.ama-assn.org/resources/doc/csaph/csaph3a08-summary.pdf
"Because the composition of HFCS and sucrose are so similar, particularly on absorption by the body, it appears unlikely that HFCS contributes more to obesity or other conditions than sucrose."
http://physrev.physiology.org/content/90/1/23.short
"Epidemiological studies show growing evidence that consumption of sweetened beverages (containing either sucrose or a mixture of glucose and fructose) is associated with a high energy intake, increased body weight, and the occurrence of metabolic and cardiovascular disorders. There is, however, no unequivocal evidence that fructose intake at moderate doses is directly related with adverse metabolic effects. There has also been much concern that consumption of free fructose, as provided in high fructose corn syrup, may cause more adverse effects than consumption of fructose consumed with sucrose. There is, however, no direct evidence for more serious metabolic consequences of high fructose corn syrup versus sucrose consumption."
But sure, let's pretend it's the HFCS and not that we've made a 1000 calorie appetizer before a 2000 calorie meal the standard for a restaurant dinner for one...
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'member dat?
True dat.