I have used both the N50 (currently on my bot PC) and the N52 (currently on my main PC). The N50 does not have the 3rd bank of keys, so I used to have /face and /stick on my quickbar ( now I have a UI with a floating window with them).
I have top row as Alternate function- 1 - 2 - 3 - 4, Shift - 5 - 6 - 7 - 8, function row as Face - Stick - Strafe left - Strafe right.
Wheel functions as mouse wheel does, but I dont use it much.
Button above D-pad as autorun.
D-pad as follows. Up = turn left
Down = turn right
Forward = walk forward (or normal movement, like forward arrow)
Back = walk backward
Space bar as Nearest Target.
I use Shift and a number to change my main quickbar pages, with slots 9 and 10 on each quickbar filled with some 'extra' funtion that is in the same family as the other spells/macros on that qbar page, but dont get used as much so I can click on them if needed.
All situational instant spells/macros are on a 2nd quickbar on my screen, and I hold my mouse pointer over that bar and scroll the wheel to scroll to the next page if needed.
Screenshot of my UI and window setup in game and my N52 key setup.
http://www.dropbox.com/gallery/3541098/1/SShot%20and%20N52%20setup%20pics?h=71ed54
When I roam around, I usually either:
1) target someone and /stick to them
2) hit auto-run
3) hold down left and right mouse buttons together.
When in combat, my stick, face, and strafe keys are very handily set, as is nearest target to nuke (with face) or smack (with stick).
Hope that helps!
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I use my N52 for EVERY game I play, if I stick with that game for any length of time. Can be programmed with different profiles for FPS games, RTS games, MMOs, you name it. I even have a 'generic FPS' profile with the generic setup just to load up when playing a new shooter.
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